Genetic Distribution of the LTA +252 A>G and TNFA -308 G > A Polymorphisms in the Moroccan Population.
Identifieur interne : 000624 ( Main/Exploration ); précédent : 000623; suivant : 000625Genetic Distribution of the LTA +252 A>G and TNFA -308 G > A Polymorphisms in the Moroccan Population.
Auteurs : Fatima Zahra Aznag [Maroc] ; Mohamed Taha Moutaoufik [Canada] ; Amal Korrida [Maroc] ; El Hassan Izaabel [Maroc]Source :
- Genetic testing and molecular biomarkers [ 1945-0257 ] ; 2019.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Allèles (MeSH), Cytokines (génétique), Déséquilibre de liaison (génétique), Facteur de nécrose tumorale alpha (génétique), Facteur de nécrose tumorale alpha (métabolisme), Facteur de nécrose tumorale alpha (sang), Femelle (MeSH), Fréquence d'allèle (génétique), Génotype (MeSH), Humains (MeSH), Lymphotoxine alpha (génétique), Lymphotoxine alpha (métabolisme), Lymphotoxine alpha (sang), Maroc (épidémiologie), Mâle (MeSH), Polymorphisme de nucléotide simple (génétique), Prédisposition génétique à une maladie (MeSH), Études cas-témoins (MeSH).
- MESH :
- génétique : Cytokines, Déséquilibre de liaison, Facteur de nécrose tumorale alpha, Fréquence d'allèle, Lymphotoxine alpha, Polymorphisme de nucléotide simple.
- métabolisme : Facteur de nécrose tumorale alpha, Lymphotoxine alpha.
- sang : Facteur de nécrose tumorale alpha, Lymphotoxine alpha.
- épidémiologie : Maroc.
- Adulte, Allèles, Femelle, Génotype, Humains, Mâle, Prédisposition génétique à une maladie, Études cas-témoins.
- Wicri :
- geographic : Maroc.
English descriptors
- KwdEn :
- Adult (MeSH), Alleles (MeSH), Case-Control Studies (MeSH), Cytokines (genetics), Female (MeSH), Gene Frequency (genetics), Genetic Predisposition to Disease (MeSH), Genotype (MeSH), Humans (MeSH), Linkage Disequilibrium (genetics), Lymphotoxin-alpha (blood), Lymphotoxin-alpha (genetics), Lymphotoxin-alpha (metabolism), Male (MeSH), Morocco (epidemiology), Polymorphism, Single Nucleotide (genetics), Tumor Necrosis Factor-alpha (blood), Tumor Necrosis Factor-alpha (genetics), Tumor Necrosis Factor-alpha (metabolism).
- MESH :
- chemical , blood : Lymphotoxin-alpha, Tumor Necrosis Factor-alpha.
- chemical , genetics : Cytokines, Lymphotoxin-alpha, Tumor Necrosis Factor-alpha.
- geographic , epidemiology : Morocco.
- genetics : Gene Frequency, Linkage Disequilibrium, Polymorphism, Single Nucleotide.
- chemical , metabolism : Lymphotoxin-alpha, Tumor Necrosis Factor-alpha.
- Adult, Alleles, Case-Control Studies, Female, Genetic Predisposition to Disease, Genotype, Humans, Male.
Abstract
Introduction: The LTA and TNFA genes encode key proinflammatory cytokines with diverse activities in the immune responses. Single nucleotide polymorphisms (SNPs) in the LTA rs909253 (+252 A > G) and TNFA rs1800629 (-308 G > A) genes have been associated with susceptibility to many complex diseases. The aim of this study was to assess the frequency for these two key polymorphisms in the Moroccan population. Materials and Methods: A total of 338 unrelated healthy Moroccan subjects were genotyped for the two alleles using a restriction fragment length polymorphism-polymerase chain reaction method. Results: The LTA (+252 A > G) and TNFA (-308 G > A) were the most common alleles with 67.9% and 74.8% frequencies, respectively. In addition to the linkage disequilibrium between the two SNPs, significant differences in allele frequencies were observed in Moroccan population compared with Mediterraneans, Europeans, Africans, South Americans, and Asians (p < 0.05). Finally, genetic proximities between Moroccan, European, and West African populations were found by means of the principal component analysis. Conclusion: The LTA +252 A>G and TNFA -308 G > A polymorphisms among Moroccan population follow the patterns commonly encountered in other Mediterranean, European, and African populations. The result of this study could contribute in developing a genetic database on the healthy Moroccan population.
DOI: 10.1089/gtmb.2019.0116
PubMed: 31738572
Affiliations:
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Zahra" uniqKey="Aznag F" first="Fatima Zahra" last="Aznag">Fatima Zahra Aznag</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir</wicri:regionArea><wicri:noRegion>Agadir</wicri:noRegion></affiliation></author><author><name sortKey="Moutaoufik, Mohamed Taha" sort="Moutaoufik, Mohamed Taha" uniqKey="Moutaoufik M" first="Mohamed Taha" last="Moutaoufik">Mohamed Taha Moutaoufik</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Regina, Regina, SK, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biochemistry, University of Regina, Regina, SK</wicri:regionArea><orgName type="university">Université de Regina</orgName><placeName><settlement type="city">Regina</settlement><region type="state">Saskatchewan</region></placeName></affiliation></author><author><name sortKey="Korrida, Amal" sort="Korrida, Amal" uniqKey="Korrida A" first="Amal" last="Korrida">Amal Korrida</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir</wicri:regionArea><wicri:noRegion>Agadir</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Higher Institute of Nursing Professions and Health Techniques of Agadir, Ministry of Health, Agadir, Morocco.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Higher Institute of Nursing Professions and Health Techniques of Agadir, Ministry of Health, Agadir</wicri:regionArea><wicri:noRegion>Agadir</wicri:noRegion></affiliation></author><author><name sortKey="Izaabel, El Hassan" sort="Izaabel, El Hassan" uniqKey="Izaabel E" first="El Hassan" last="Izaabel">El Hassan Izaabel</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir, Morocco.</nlm:affiliation><country xml:lang="fr">Maroc</country><wicri:regionArea>Laboratory of Cellular Biology and Molecular Genetics, Faculty of Sciences, Ibn Zohr University, Agadir</wicri:regionArea><wicri:noRegion>Agadir</wicri:noRegion></affiliation></author></analytic><series><title level="j">Genetic testing and molecular biomarkers</title><idno type="eISSN">1945-0257</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Alleles (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Cytokines (genetics)</term><term>Female (MeSH)</term><term>Gene Frequency (genetics)</term><term>Genetic Predisposition to Disease (MeSH)</term><term>Genotype (MeSH)</term><term>Humans (MeSH)</term><term>Linkage Disequilibrium (genetics)</term><term>Lymphotoxin-alpha (blood)</term><term>Lymphotoxin-alpha (genetics)</term><term>Lymphotoxin-alpha (metabolism)</term><term>Male (MeSH)</term><term>Morocco (epidemiology)</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>Tumor Necrosis Factor-alpha (blood)</term><term>Tumor Necrosis Factor-alpha (genetics)</term><term>Tumor Necrosis Factor-alpha (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Allèles (MeSH)</term><term>Cytokines (génétique)</term><term>Déséquilibre de liaison (génétique)</term><term>Facteur de nécrose tumorale alpha (génétique)</term><term>Facteur de nécrose tumorale alpha (métabolisme)</term><term>Facteur de nécrose tumorale alpha (sang)</term><term>Femelle (MeSH)</term><term>Fréquence d'allèle (génétique)</term><term>Génotype (MeSH)</term><term>Humains (MeSH)</term><term>Lymphotoxine alpha (génétique)</term><term>Lymphotoxine alpha (métabolisme)</term><term>Lymphotoxine alpha (sang)</term><term>Maroc (épidémiologie)</term><term>Mâle (MeSH)</term><term>Polymorphisme de nucléotide simple (génétique)</term><term>Prédisposition génétique à une maladie (MeSH)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Lymphotoxin-alpha</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytokines</term><term>Lymphotoxin-alpha</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Morocco</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Frequency</term><term>Linkage Disequilibrium</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cytokines</term><term>Déséquilibre de liaison</term><term>Facteur de nécrose tumorale alpha</term><term>Fréquence d'allèle</term><term>Lymphotoxine alpha</term><term>Polymorphisme de nucléotide simple</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Lymphotoxin-alpha</term><term>Tumor Necrosis Factor-alpha</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term><term>Lymphotoxine alpha</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Facteur de nécrose tumorale alpha</term><term>Lymphotoxine alpha</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Maroc</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Alleles</term><term>Case-Control Studies</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Genotype</term><term>Humans</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Allèles</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Prédisposition génétique à une maladie</term><term>Études cas-témoins</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Maroc</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><b><i>Introduction:</i></b> The <i>LTA</i> and <i>TNFA</i> genes encode key proinflammatory cytokines with diverse activities in the immune responses. Single nucleotide polymorphisms (SNPs) in the <i>LTA</i> rs909253 (+252 A > G) and <i>TNFA</i> rs1800629 (-308 G > A) genes have been associated with susceptibility to many complex diseases. The aim of this study was to assess the frequency for these two key polymorphisms in the Moroccan population. <b><i>Materials and Methods:</i></b> A total of 338 unrelated healthy Moroccan subjects were genotyped for the two alleles using a restriction fragment length polymorphism-polymerase chain reaction method. <b><i>Results:</i></b> The <i>LTA</i> (+252 A > G) and <i>TNFA</i> (-308 G > A) were the most common alleles with 67.9% and 74.8% frequencies, respectively. In addition to the linkage disequilibrium between the two SNPs, significant differences in allele frequencies were observed in Moroccan population compared with Mediterraneans, Europeans, Africans, South Americans, and Asians (<i>p</i> < 0.05). Finally, genetic proximities between Moroccan, European, and West African populations were found by means of the principal component analysis. <b><i>Conclusion:</i></b> The <i>LTA</i> +252 A>G and <i>TNFA</i> -308 G > A polymorphisms among Moroccan population follow the patterns commonly encountered in other Mediterranean, European, and African populations. The result of this study could contribute in developing a genetic database on the healthy Moroccan population.</div></front></TEI><affiliations><list><country><li>Canada</li><li>Maroc</li></country><region><li>Saskatchewan</li></region><settlement><li>Regina</li></settlement><orgName><li>Université de Regina</li></orgName></list><tree><country name="Maroc"><noRegion><name sortKey="Aznag, Fatima Zahra" sort="Aznag, Fatima Zahra" uniqKey="Aznag F" first="Fatima Zahra" last="Aznag">Fatima Zahra Aznag</name></noRegion><name sortKey="Izaabel, El Hassan" sort="Izaabel, El Hassan" uniqKey="Izaabel E" first="El Hassan" last="Izaabel">El Hassan Izaabel</name><name sortKey="Korrida, Amal" sort="Korrida, Amal" uniqKey="Korrida A" first="Amal" last="Korrida">Amal Korrida</name><name sortKey="Korrida, Amal" sort="Korrida, Amal" uniqKey="Korrida A" first="Amal" last="Korrida">Amal Korrida</name></country><country name="Canada"><region name="Saskatchewan"><name sortKey="Moutaoufik, Mohamed Taha" sort="Moutaoufik, Mohamed Taha" uniqKey="Moutaoufik M" first="Mohamed Taha" last="Moutaoufik">Mohamed Taha Moutaoufik</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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